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Today, I’m joined once again by neuroscientist Siobhan Mitchell for a conversation that will totally reframe how you think about creatine. Siobhan is here to break down why this simple supplement might actually be one of the most powerful and underappreciated tools for longevity, brain health, and overall resilience as we age.
Read MoreToday, I’m joined by Steve Scott, an entrepreneur, researcher, and author of The Carbonated Body, who is on a mission to change the way we think about carbon dioxide—and trust me, it’s not just a waste gas. In this episode, Steve makes a compelling case for why CO2 is vital for better energy, resilient mitochondria, and improved recove
Read MoreIn this eye-opening conversation, we break down how microplastics don’t just clutter our environment—they infiltrate our bodies, disrupt cellular energy, drive chronic inflammation, and even pass through to future generations. We also get real about the hidden sources of plastic exposure all around us, including the products we think are “healthy,” and why our companion animals may be the environmental sentinels we’ve been ignoring.
Read MoreToday, I’m joined by Wade Lightheart, a true thought leader in the world of biohacking and co-founder of BiOptimizers. Wade has spent decades diving deep into the science of longevity—questioning what really moves the needle for our long-term health, and challenging some of the biggest assumptions in the wellness industry.
Read MoreToday, I’m joined by Scott Hickle, former SpaceX engineer and the innovative co-founder of Throne Science (use code LISTENTOYOURGUT for $50 off) —the company on a mission to transform your toilet into a powerful tool for understanding your health. In our conversation, Scott shares how a casual poker night conversation turned into a game-changing pursuit to unlock the health secrets hidden in our daily bathroom routines, (we’re talking about your poop and pee) and why gut health has long been a blind spot for those tracking every other health metric.
Read MoreToday, I’m diving solo into a topic that’s truly at the heart of everything I do: longevity—specifically, how to actually feel vibrant and strong as we age, not just rack up more years on the calendar. I break down the science behind aging, the real reasons why our repair systems start to slow down, and the practical ways we can take charge, starting right now.
Read MoreToday, I’m joined by the exceptional Dr. Laura James, a breast cancer specialist who has spent over two decades guiding women through conventional treatment and integrative care. In our conversation, Dr. James opens up about the real struggles women face beyond the diagnosis—everything from family dynamics and workplace challenges to the “unmentionables” like body image, sexuality, and grief. She shares how her personal journey with chronic illness shaped her unique approach to truly supporting the whole person, not just the disease.
Read MoreToday, I’m joined by the incredible Dr. Nora Abdul-Hussein, a physician-scientist, medical geneticist, and one of the leading voices in the field of genomic medicine. In this episode, Dr. Abdul-Hussein and I dig into a huge question—why do two people taking the exact same GLP-1 medication have such wildly different results, from weight loss to side effect profiles? She shares her unique path from internal medicine to cutting-edge population genomics, and how her work at 23andMe is beginning to answer some of medicine’s toughest puzzles.
Read MoreToday, I’m joined by Dan Pardi, a pioneering researcher who has dedicated years to understanding sleep, performance, and—the real focus of today’s conversation—the science of human energy. Dan unpacks how modern life is quietly draining our brain’s battery, and why brain energy, not just the march of time, could be the hidden driver of longevity.
Read MoreToday, I’m joined by Dr. Elisa Port, a trailblazing breast cancer surgeon and passionate advocate for women’s health. And the author of The Breast Advice In our conversation, Dr. Port traces her evolution from general surgery into breast surgery, sharing how the deeply collaborative decision-making with patients became her life’s calling. She gives an inside look at the optimism she found in this field—where advances in treatment have dramatically improved survival, offering hope and empowerment to countless women.
Read MoreToday, I’m joined by Dr. Jill Crista, a pioneering voice in environmental medicine and a relentless detective when it comes to chronic, mysterious illness. In our conversation, Dr. Crista reveals how she uncovered the hidden world of mold and mycotoxins—not just as respiratory irritants, but as stealthy drivers of fatigue, brain fog, hormone disruption, and accelerated aging. She shares her early experiences working with “non-responders” in Lyme disease, and how uncovering toxic mold exposures transformed her entire understanding of whole-body health.
Read MoreToday, I’m joined by Dr. Bill Lawrence, a leading researcher in longevity and pioneer in clinical studies on peptide bioregulators. Over the past eight years, Dr. Lawrence has dedicated himself to asking the big questions in longevity science: Do these interventions really work, and which strategies actually move the needle when it comes to living longer, healthier lives?
Read MoreToday, I’m mixing things up with a special episode that takes you on a tour through some of the most compelling moments from the past quarter. Rather than a typical interview or solo deep dive, I’ve curated standout clips from episodes that lit a fire under important longevity conversations and resonated deeply with both me and the team.
Read MoreFor years, we've been told to prioritize our muscles, our hormones, and our heart health—but what about our brains? Today's conversation explores why women are at a greater risk for Dementia and Alzheimer's, why brain changes begin decades before symptoms appear, and why so many warning signs are dismissed as "just stress" or "just menopause."
Read MoreMy guest today is James LaValle R.Ph., C.C.N. M.T. DHM, DHPh, one of the pioneers in functional and metabolic medicine, and we're unpacking the silent process he calls metaflammation—the chronic, low-grade inflammation that can quietly drive everything from fatigue and insulin resistance to hormone imbalances and accelerated aging.
Read MoreFollow my NEW Instagram @longevitywithnat
Most people think that if they can just find the right mold test, they'll finally have their answer. But what if that's exactly what's keeping them stuck? In this episode, I'm joined once again by mold investigator and building health expert Jason Earle, and we challenge some of the biggest assumptions surrounding mold illness.
Read MoreFor years we've talked about longevity as if the answer is hiding in the next supplement, biomarker, or miracle molecule. But what if we've been looking at aging through far too narrow a lens? Today's guest, Dr. Marios Kyriazis, has spent decades challenging that idea by exploring aging through medicine, complexity science, cybernetics, and even philosophy.
Read MoreIf you've been hearing everyone talk about exosomes but still aren't exactly sure what they are—or whether they're actually worth the hype—this episode is for you. Today I'm joined once again by Amitay Eshel and Anastasia Khodzhaeva from Young Goose to separate the science from the marketing and unpack what exosomes are really doing inside your skin.
Read MoreToday, I’m joined by the insightful Dr. Scott Sherr, a pioneer in health optimization and mitochondrial medicine. In our conversation, Dr. Sherr introduces his groundbreaking concept—the "sympathetic spiral of doom"—and explains why so many high performers end up burned out, frustrated, and feeling like their nervous systems are working against them.
Read MoreToday, I’m joined by Dr. Teo Soleymani, a renowned dermatological oncologist whose unique vantage point bridges the worlds of conventional medicine and longevity science. As someone who sees the real consequences of UV damage in his surgical practice while also advocating for a balanced, evidence-driven approach to sunlight and skin health, Dr. Teo Soleymani isn’t afraid to challenge the most entrenched ideas in modern skincare.
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