Posts tagged immune system
#460: Most Impactful Pod Moments: Hidden Cancer Markers, Radical Longevity Experiments, EMFs Exposed (and the Mast Cell Dilemma) With Nathalie Niddam & Guests

Today, I’m mixing things up with a special episode that takes you on a tour through some of the most compelling moments from the past quarter. Rather than a typical interview or solo deep dive, I’ve curated standout clips from episodes that lit a fire under important longevity conversations and resonated deeply with both me and the team.

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#456: The Bioregulator Debate: What Actually Works (And What Doesn't) With Dr Marios Kyriazis

For years we've talked about longevity as if the answer is hiding in the next supplement, biomarker, or miracle molecule. But what if we've been looking at aging through far too narrow a lens? Today's guest, Dr. Marios Kyriazis, has spent decades challenging that idea by exploring aging through medicine, complexity science, cybernetics, and even philosophy.

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#454: From Burnout to Balance: Rebuilding Cellular Energy & Getting Out Of Fight Or Flight With Scott Sherr

Today, I’m joined by the insightful Dr. Scott Sherr, a pioneer in health optimization and mitochondrial medicine. In our conversation, Dr. Sherr introduces his groundbreaking concept—the "sympathetic spiral of doom"—and explains why so many high performers end up burned out, frustrated, and feeling like their nervous systems are working against them.

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#450: Lyme, Bartonella & Babesia EXPOSED: Hidden Vectors, Lost Lives, and the Battle for Early Detection With Nicole Bell

Today, I’m joined by Nicole Bell, an accomplished engineer who made an unexpected leap from designing cutting-edge surgical robotics to becoming a powerful advocate for better diagnostics in tick-borne diseases. Nicole’s story is both deeply personal and urgent: after her husband was misdiagnosed with early-onset Alzheimer’s—only to later discover the true culprit was hidden tick-borne infections—she set out to uncover why our medical system misses these subtle yet devastating conditions.

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#447: Gut AWAKENING: The Silent Epidemic of Spike Protein, Long Covid, and Accelerated Aging | Dr. Robin Rose

Today, I’m joined by Dr. Robin Rose, a double board-certified gastroenterologist and internal medicine physician who has become a true pioneer in the space of functional and precision medicine. Driven by a relentless curiosity that survived even the most rigid medical training, Dr. Rose shares how her quest to answer “why” led her beyond conventional medicine into root-cause healing, patient-centered care, and the world of gut health, biochemistry, and the microbiome.

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#444: Stop Negative Thought Spirals With This Framework | Learn How Rumination Affects Your Health With Donna Jackson Nakazawa

Today, I’m joined by the incredibly insightful Donna Jackson Nakazawa, a science journalist and bestselling author whose work bridges the worlds of neuroscience, storytelling, and personal transformation. Donna has a unique gift for translating complex brain science into real-life strategies—and she’s not afraid to weave in her own powerful journey, from childhood trauma and autoimmune challenges to her fierce quest for hope and healing.

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#439: Reclaiming Metabolism: The SECRET Molecule Transforming Women's Health (Belly Fat, Brain Power & Beyond) With Siobhan Mitchell PhD

Today, I’m joined by the insightful Siobhan Mitchell PhD, a leading expert on women’s health, mitochondria, and metabolic resilience. In our conversation, Siobhan reveals why so many women in their 30s and 40s feel like their metabolism is suddenly “broken,” and unpacks the real science behind what’s happening beneath the surface—especially as our hormones begin to shift.

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#436: Is Your Body’s Terrain Hospitable For Cancer? Affordable Lab Tests, Metabolic Flexibility, and Emotional Foundations With Dr. Nasha Winters

Today, I’m thrilled to welcome Dr. Nasha Winters back to the show for part two of our powerful conversation. As a trailblazer in integrative oncology and a passionate advocate for the “metabolic terrain” approach to health, Dr. Winters brings both deep expertise and a truly holistic perspective to the complex world of cancer and longevity. In this episode, she doesn’t just share concepts—she takes us into the heart of what it means to test, assess, and address our own health in real life, especially when we’re facing major diagnoses and difficult decisions.

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#434: Are You Aging Like Someone Else? (How To Find Your PERSONAL Path to Healthspan) With Sandra Kaufmann.

Today, I’m joined by the one and only Dr. Sandra Kaufmann—a true pioneer in the field of personalized longevity medicine and the creative force behind the Kaufman Protocol. In this episode, Sandra shares how a personal curiosity about why we age at the cellular level ultimately drew her away from a successful anesthesia career and into the world of building longevity strategies for real people. She opens up about the moment longevity became more than just an intellectual pursuit, and the surprising ways her work has grown into a global movement.

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#432: Midlife Wake-Up Call: Why Doing Less Is Important During The Peri- and Menopausal Transition With Cynthia Thurlow

Today, I’m joined by the insightful Cynthia Thurlow, a leading voice in women’s health and the acclaimed author of The Menopause Gut. In this episode, Cynthia Thurlow gets real about the chaos of perimenopause—a time when so many women look in the mirror and ask, “Who is this?” She opens up about why this transition, often dismissed or misunderstood, is actually a powerful wake-up call and a pivotal moment to reclaim our well-being.

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#428: Poop, Peptides & The Power of Microbiome | The Secret Longevity Organ With Dr. Grace Liu

Today, I'm joined by Dr. Grace Liu, often known as the “Gut Goddess,” a trailblazer in the world of microbiome science and founder of The Gut Institute. In this conversation, we take a bold dive into an often-overlooked pillar of longevity: your poop. That's right—Dr. Liu unpacks the fascinating and sometimes surprising science showing how gut health shapes everything from your immune system and brain to your lifespan itself.

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#425: Broccoli Power: The Secret Longevity Molecule (Fighting Toxins, Microplastics & Aging) | Sulforaphane Exposed With David Roberts & Dr. John Gildea

Today, I’m joined by David Roberts and Dr. John Gildea, two passionate researchers whose work sits at the cutting edge of environmental health and longevity science. In this episode, we dive deep into the catalyst for developing a stabilized sulforaphane supplement—something born out of both necessity and relentless curiosity. David opens up about how environmental toxicity stopped being theoretical for him, and Dr. Gildea brings a wealth of clinical insight into why supporting our detox pathways could be a game-changer for chronic disease prevention.

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#424: Part 2 - Follow Up To Dr. Bill Lawrence Episode: Answering More Of Your Bioregulator Questions With Nat Niddam & Erin Ryan

Today, I’m joined by Erin Ryan, my producer, for a special follow-up episode where we tackle your most pressing questions about bioregulators and peptides. After our wildly popular Bill Lawrence interview, the Longevity Podcast community sent in a wave of thoughtful queries—from cancer concerns to menopause, sourcing, and practical tips.

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#421: Trauma SCIENCE: How Hidden Stress Hijacks Your Health (Autoimmunity, Brain Inflammation, and Unlocking Resilience) | With Dr. Aimie Apigian

Today, I’m joined by Dr. Aimie Apigian, an innovative leader in the biology of trauma, whose work bridges the worlds of science, medicine, and lived experience. In our conversation, Dr. Apigian opens up about her journey from conventional medicine—where symptom management was the norm—to uncovering the physiological roots of trauma and the crucial role our nervous system plays in resilience and healing. She shares how her own health struggles, her work with adopted children, and a relentless curiosity led her to re-examine everything she thought she knew about stress, autoimmunity, and capacity.

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#420: Spermidine UNLOCKED: Reverse Aging, Boost Immunity & Thrive After 40 With Leslie Kenny

Today, I'm joined by the inspiring Leslie Kenny, Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable.

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#415: The Untold Truth About Heart Health: (Women, Genetics & the JOY of Longevity) | Dr. Regina Druz Reveals All

Today, I’m joined by Erin Ryan, my producer and long-time collaborator, for a special Q&A episode powered entirely by your questions. After our bioregulator deep dive with Dr. Bill Lawrence, the response was overwhelming—so many of you reached out with insightful queries about bioregulators, peptides, and the nuances between natural and synthetic options. Erin and I decided to tackle the most common themes, unpacking everything from organ versus system signaling to how bioregulators actually survive digestion.

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#400: Why Chasing Muscle for Longevity Might Backfire: The Real Keys to Aging Well With Joel Greene

Today, I’m excited to bring back the always thought-provoking Joel Greene, author of “The Immunity Code” and “The Way,” for a fresh conversation on why true longevity is about so much more than how much muscle you have or the latest diet trend you’re following. Joel Greene opens up about the hard lessons he’s learned from decades of self-experimentation and reveals why chasing that ideal gym physique might actually backfire as you age.

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#399:Longevity Rewired: Hormones, Sunlight & The Weight Loss LIE | Reversing Aging in 2025 With Nat Niddam

Today, I’m joined by a lineup of trailblazers in the science of longevity: Ben Azadi, Dr. Teo Soleymani, Dr. Carrie Jones, Ian White, Dr. Robert Lufkin, and Dr. Jenn Simmons . Together we dig into some of the most persistent myths and cutting-edge research shaping how we age—including why “eat less, move more” misses the mark, what really causes skin cancers, breast cancer screening risks, and the often-overlooked ripple effects of perimenopause.

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#396: From Trauma to Transcendence: Alpha Training, Elite Creativity Gains, and Reversing Aging — With Dr. James Hardt

Today, I’m joined by Dr. James Hardt—founder of Biocybernaut and a true pioneer in the world of neurofeedback. With over four decades spent mapping how our brainwaves shape emotions, performance, and even identity, Dr. Hardt has helped reframe the conversation around unlocking human potential, making cutting-edge brain training accessible to seekers, creatives, and everyday biohackers alike.

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#394 How Bioregulator Peptides HALVE Mortality: Telomere Reversal, Organs REGENERATED & the 8-Year Experiment With Dr. Bill Lawrence

Today, I’m joined once again by the incredible Dr. Bill Lawrence, a true pioneer in the field of longevity research and one of the most requested guests on this podcast. Dr. Lawrence trained directly with Professor Vladimir Khavinson—the scientist who discovered and developed bioregulator peptides—and has spent the last eight years leading some of the most exciting field research in this space.

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