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In this eye-opening conversation, we break down how microplastics don’t just clutter our environment—they infiltrate our bodies, disrupt cellular energy, drive chronic inflammation, and even pass through to future generations. We also get real about the hidden sources of plastic exposure all around us, including the products we think are “healthy,” and why our companion animals may be the environmental sentinels we’ve been ignoring.
Read MoreToday, I’m joined by Scott Hickle, former SpaceX engineer and the innovative co-founder of Throne Science (use code LISTENTOYOURGUT for $50 off) —the company on a mission to transform your toilet into a powerful tool for understanding your health. In our conversation, Scott shares how a casual poker night conversation turned into a game-changing pursuit to unlock the health secrets hidden in our daily bathroom routines, (we’re talking about your poop and pee) and why gut health has long been a blind spot for those tracking every other health metric.
Read MoreToday, I’m joined by the incredible Dr. Nora Abdul-Hussein, a physician-scientist, medical geneticist, and one of the leading voices in the field of genomic medicine. In this episode, Dr. Abdul-Hussein and I dig into a huge question—why do two people taking the exact same GLP-1 medication have such wildly different results, from weight loss to side effect profiles? She shares her unique path from internal medicine to cutting-edge population genomics, and how her work at 23andMe is beginning to answer some of medicine’s toughest puzzles.
Read MoreToday, I’m joined by Dan Pardi, a pioneering researcher who has dedicated years to understanding sleep, performance, and—the real focus of today’s conversation—the science of human energy. Dan unpacks how modern life is quietly draining our brain’s battery, and why brain energy, not just the march of time, could be the hidden driver of longevity.
Read MoreToday, I’m joined by Dr. Elisa Port, a trailblazing breast cancer surgeon and passionate advocate for women’s health. And the author of The Breast Advice In our conversation, Dr. Port traces her evolution from general surgery into breast surgery, sharing how the deeply collaborative decision-making with patients became her life’s calling. She gives an inside look at the optimism she found in this field—where advances in treatment have dramatically improved survival, offering hope and empowerment to countless women.
Read MoreToday, I’m joined by Dr. Bill Lawrence, a leading researcher in longevity and pioneer in clinical studies on peptide bioregulators. Over the past eight years, Dr. Lawrence has dedicated himself to asking the big questions in longevity science: Do these interventions really work, and which strategies actually move the needle when it comes to living longer, healthier lives?
Read MoreToday, I’m mixing things up with a special episode that takes you on a tour through some of the most compelling moments from the past quarter. Rather than a typical interview or solo deep dive, I’ve curated standout clips from episodes that lit a fire under important longevity conversations and resonated deeply with both me and the team.
Read MoreFor years, we've been told to prioritize our muscles, our hormones, and our heart health—but what about our brains? Today's conversation explores why women are at a greater risk for Dementia and Alzheimer's, why brain changes begin decades before symptoms appear, and why so many warning signs are dismissed as "just stress" or "just menopause."
Read MoreMy guest today is James LaValle R.Ph., C.C.N. M.T. DHM, DHPh, one of the pioneers in functional and metabolic medicine, and we're unpacking the silent process he calls metaflammation—the chronic, low-grade inflammation that can quietly drive everything from fatigue and insulin resistance to hormone imbalances and accelerated aging.
Read MoreFollow my NEW Instagram @longevitywithnat
Most people think that if they can just find the right mold test, they'll finally have their answer. But what if that's exactly what's keeping them stuck? In this episode, I'm joined once again by mold investigator and building health expert Jason Earle, and we challenge some of the biggest assumptions surrounding mold illness.
Read MoreFor years we've talked about longevity as if the answer is hiding in the next supplement, biomarker, or miracle molecule. But what if we've been looking at aging through far too narrow a lens? Today's guest, Dr. Marios Kyriazis, has spent decades challenging that idea by exploring aging through medicine, complexity science, cybernetics, and even philosophy.
Read MoreIf you've been hearing everyone talk about exosomes but still aren't exactly sure what they are—or whether they're actually worth the hype—this episode is for you. Today I'm joined once again by Amitay Eshel and Anastasia Khodzhaeva from Young Goose to separate the science from the marketing and unpack what exosomes are really doing inside your skin.
Read MoreToday, I’m joined by the insightful Dr. Scott Sherr, a pioneer in health optimization and mitochondrial medicine. In our conversation, Dr. Sherr introduces his groundbreaking concept—the "sympathetic spiral of doom"—and explains why so many high performers end up burned out, frustrated, and feeling like their nervous systems are working against them.
Read MoreToday, I’m joined once again by the innovative Ian Mitchell, a name familiar to anyone passionate about radical longevity, biohacking, and pushing the boundaries of human performance. In this conversation, Ian pulls back the curtain on the science and surprising applications of C60—known as the “buckyball” molecule—and why it’s become such a powerful tool for both peak performance and healthy aging.
Read MoreToday, I’m joined by Dr. Andrew Salzman, a pioneer in NAD research whose work has spanned everything from pediatric sepsis to cutting-edge longevity science. Dr. Salzman dives deep into why NAD isn’t just another supplement buzzword, but a central molecule powering our energy, resilience, and even fertility.
Read MoreToday, I’m joined by the incredibly insightful Donna Jackson Nakazawa, a science journalist and bestselling author whose work bridges the worlds of neuroscience, storytelling, and personal transformation. Donna has a unique gift for translating complex brain science into real-life strategies—and she’s not afraid to weave in her own powerful journey, from childhood trauma and autoimmune challenges to her fierce quest for hope and healing.
Read MoreToday, I’m joined by Dr. William Davis, a cardiologist-turned-gut detective and bestselling author behind Wheat Belly, Super Gut, and Super Body. In this episode, Dr. Davis breaks down what it really means to have youthful, functional muscle, why maintaining the muscle of your 20s and 30s is about so much more than hitting the gym, and how missing microbes—like L. reuteri—might be the secret to restoring your strength and energy.
Read MoreToday, I’m flying solo to tackle a topic that’s essential for anyone invested in their health: how to truly vet your supplements. With new products hitting the shelves daily and wellness marketing louder than ever, it’s easy to get swept up in the latest hype—but more isn’t always better, and sometimes it can actually make things worse. In this episode, I break down the six key filters I use before adding any supplement to my routine, from understanding your baseline biomarkers to decoding red flags in marketing language like “studies show.” I dig into common pitfalls—like why “natural” doesn’t automatically mean safe, the real risks of fat-soluble vitamin toxicity, and how to spot quality with third-party certifications.
Read MoreToday, I’m joined by the insightful Siobhan Mitchell PhD, a leading expert on women’s health, mitochondria, and metabolic resilience. In our conversation, Siobhan reveals why so many women in their 30s and 40s feel like their metabolism is suddenly “broken,” and unpacks the real science behind what’s happening beneath the surface—especially as our hormones begin to shift.
Read MoreToday, I’m joined by the incredible Dr. Amie Hornaman, a leading thyroid expert and author of the brand new book, The Thyroid Fix. In our conversation, Dr. Hornaman opens up about her personal struggle with undiagnosed thyroid disease—a journey marked by frustrating medical gaslighting and the dismissive “you’re normal” diagnoses from doctor after doctor. She reveals how that experience led her to become a passionate advocate for women (and men) suffering from thyroid dysfunction and a pioneer in holistic, root-cause approaches to healing.
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