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Today, I’m mixing things up with a special episode that takes you on a tour through some of the most compelling moments from the past quarter. Rather than a typical interview or solo deep dive, I’ve curated standout clips from episodes that lit a fire under important longevity conversations and resonated deeply with both me and the team.
Read MoreFor years, we've been told to prioritize our muscles, our hormones, and our heart health—but what about our brains? Today's conversation explores why women are at a greater risk for Dementia and Alzheimer's, why brain changes begin decades before symptoms appear, and why so many warning signs are dismissed as "just stress" or "just menopause."
Read MoreMy guest today is James LaValle R.Ph., C.C.N. M.T. DHM, DHPh, one of the pioneers in functional and metabolic medicine, and we're unpacking the silent process he calls metaflammation—the chronic, low-grade inflammation that can quietly drive everything from fatigue and insulin resistance to hormone imbalances and accelerated aging.
Read MoreFollow my NEW Instagram @longevitywithnat
Most people think that if they can just find the right mold test, they'll finally have their answer. But what if that's exactly what's keeping them stuck? In this episode, I'm joined once again by mold investigator and building health expert Jason Earle, and we challenge some of the biggest assumptions surrounding mold illness.
Read MoreFor years we've talked about longevity as if the answer is hiding in the next supplement, biomarker, or miracle molecule. But what if we've been looking at aging through far too narrow a lens? Today's guest, Dr. Marios Kyriazis, has spent decades challenging that idea by exploring aging through medicine, complexity science, cybernetics, and even philosophy.
Read MoreIf you've been hearing everyone talk about exosomes but still aren't exactly sure what they are—or whether they're actually worth the hype—this episode is for you. Today I'm joined once again by Amitay Eshel and Anastasia Khodzhaeva from Young Goose to separate the science from the marketing and unpack what exosomes are really doing inside your skin.
Read MoreToday, I’m joined by the insightful Dr. Scott Sherr, a pioneer in health optimization and mitochondrial medicine. In our conversation, Dr. Sherr introduces his groundbreaking concept—the "sympathetic spiral of doom"—and explains why so many high performers end up burned out, frustrated, and feeling like their nervous systems are working against them.
Read MoreToday, I’m joined once again by the innovative Ian Mitchell, a name familiar to anyone passionate about radical longevity, biohacking, and pushing the boundaries of human performance. In this conversation, Ian pulls back the curtain on the science and surprising applications of C60—known as the “buckyball” molecule—and why it’s become such a powerful tool for both peak performance and healthy aging.
Read MoreToday, I’m joined by Dr. Andrew Salzman, a pioneer in NAD research whose work has spanned everything from pediatric sepsis to cutting-edge longevity science. Dr. Salzman dives deep into why NAD isn’t just another supplement buzzword, but a central molecule powering our energy, resilience, and even fertility.
Read MoreToday, I’m joined by the incredibly insightful Donna Jackson Nakazawa, a science journalist and bestselling author whose work bridges the worlds of neuroscience, storytelling, and personal transformation. Donna has a unique gift for translating complex brain science into real-life strategies—and she’s not afraid to weave in her own powerful journey, from childhood trauma and autoimmune challenges to her fierce quest for hope and healing.
Read MoreToday, I’m joined by Dr. William Davis, a cardiologist-turned-gut detective and bestselling author behind Wheat Belly, Super Gut, and Super Body. In this episode, Dr. Davis breaks down what it really means to have youthful, functional muscle, why maintaining the muscle of your 20s and 30s is about so much more than hitting the gym, and how missing microbes—like L. reuteri—might be the secret to restoring your strength and energy.
Read MoreToday, I’m flying solo to tackle a topic that’s essential for anyone invested in their health: how to truly vet your supplements. With new products hitting the shelves daily and wellness marketing louder than ever, it’s easy to get swept up in the latest hype—but more isn’t always better, and sometimes it can actually make things worse. In this episode, I break down the six key filters I use before adding any supplement to my routine, from understanding your baseline biomarkers to decoding red flags in marketing language like “studies show.” I dig into common pitfalls—like why “natural” doesn’t automatically mean safe, the real risks of fat-soluble vitamin toxicity, and how to spot quality with third-party certifications.
Read MoreToday, I’m joined by the insightful Siobhan Mitchell PhD, a leading expert on women’s health, mitochondria, and metabolic resilience. In our conversation, Siobhan reveals why so many women in their 30s and 40s feel like their metabolism is suddenly “broken,” and unpacks the real science behind what’s happening beneath the surface—especially as our hormones begin to shift.
Read MoreToday, I’m joined by the incredible Dr. Amie Hornaman, a leading thyroid expert and author of the brand new book, The Thyroid Fix. In our conversation, Dr. Hornaman opens up about her personal struggle with undiagnosed thyroid disease—a journey marked by frustrating medical gaslighting and the dismissive “you’re normal” diagnoses from doctor after doctor. She reveals how that experience led her to become a passionate advocate for women (and men) suffering from thyroid dysfunction and a pioneer in holistic, root-cause approaches to healing.
Read MoreToday, I’m thrilled to welcome Dr. Nasha Winters back to the show for part two of our powerful conversation. As a trailblazer in integrative oncology and a passionate advocate for the “metabolic terrain” approach to health, Dr. Winters brings both deep expertise and a truly holistic perspective to the complex world of cancer and longevity. In this episode, she doesn’t just share concepts—she takes us into the heart of what it means to test, assess, and address our own health in real life, especially when we’re facing major diagnoses and difficult decisions.
Read MoreToday, I’m joined by the insightful Caroline Alan, author of The Mineral Reset and co-founder of Beam Minerals. Caroline Alan shares her powerful story—a decade-long journey from chronic fatigue, brain fog, adrenal burnout, and persistent health challenges to discovering the true foundation of her recovery: replenishing trace minerals. After years of searching for answers and seeing countless specialists, it wasn’t another diet or protocol that brought her back to health, but addressing a deep, often-overlooked mineral deficiency.
Read MoreToday, I'm joined by Dr. Grace Liu, often known as the “Gut Goddess,” a trailblazer in the world of microbiome science and founder of The Gut Institute. In this conversation, we take a bold dive into an often-overlooked pillar of longevity: your poop. That's right—Dr. Liu unpacks the fascinating and sometimes surprising science showing how gut health shapes everything from your immune system and brain to your lifespan itself.
Read MoreToday, I’m joined by the insightful Dr. Meenal Agarwal, an eye doctor and passionate advocate for reimagining how we think about vision and brain health. In our conversation, Dr. Agarwal reveals the surprising ways our daily screen habits are shaping not just our eyesight, but also our emotional regulation, cognitive performance, and even the development of anxiety and ADHD-like symptoms. She opens up about her own journey—from an unexpected period of cognitive “off-ness” during a stint away from her clinical work, to pioneering a powerful perspective on “spatial awareness processing disorder.”
Read MoreToday, I’m joined by the amazing Melissa Urban, the force behind Whole30 and a global champion of accessible nutrition. In our conversation, Melissa opens up about a surprising discovery in her wellness journey: sleep, not just food, is often the real foundation of long-term health. She shares how overlooked sleep hijacked her cravings, impacted her insulin sensitivity, and even chipped away at her resilience—revealing the invisible costs that only show up years down the line.
Read MoreToday, I’m joined by David Roberts and Dr. John Gildea, two passionate researchers whose work sits at the cutting edge of environmental health and longevity science. In this episode, we dive deep into the catalyst for developing a stabilized sulforaphane supplement—something born out of both necessity and relentless curiosity. David opens up about how environmental toxicity stopped being theoretical for him, and Dr. Gildea brings a wealth of clinical insight into why supporting our detox pathways could be a game-changer for chronic disease prevention.
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