#406: Peptide OVERLOAD: When Biohacking Backfires (How NOT to Crash Your Mitochondria) With Anthony Castore
Today, I’m joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.
Together, we dig into how cellular pathways like AMPK and mTOR influence everything from muscle growth to longevity, why you don’t have to choose between training hard and aging well, and how Anthony’s integrative approach can amplify the rewards of your workouts while supporting long-term resilience. He opens up about his own missteps with “stacking” too many interventions at once, and the hard-won wisdom that followed.
If you’re curious about optimizing performance and health for the long haul, this episode is packed with actionable insights on personalized training, peptide support, foundational recovery, and building a body—and life—that’s built to last.
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Learn more from Anthony Castore below:
Instagram: @anthonycastore
Products: https://alchemiqlabs.com/ (use NAT10 for 10% off)
What We Discuss:
Welcome and episode introduction ... 00:00:00
Anthony Castore’s path from strength coaching to cellular medicine ... 00:05:55
Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27
Explaining and balancing AMPK and mTOR for performance ... 00:13:03
Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18
Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04
Assessing recovery capacity and individualizing protocols ... 00:26:02
Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57
Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00
Differentiating bodybuilder vs. longevity approaches ... 00:34:44
Integrating peptides and support molecules into routines ... 00:40:44
Ketone esters and mitochondrial peptide interventions ... 00:41:20
Cautions on stacking and combining interventions ... 00:54:04
Lessons learned from overdoing interventions ... 01:05:02
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