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My guest today is James LaValle R.Ph., C.C.N. M.T. DHM, DHPh, one of the pioneers in functional and metabolic medicine, and we're unpacking the silent process he calls metaflammation—the chronic, low-grade inflammation that can quietly drive everything from fatigue and insulin resistance to hormone imbalances and accelerated aging.
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Most people think that if they can just find the right mold test, they'll finally have their answer. But what if that's exactly what's keeping them stuck? In this episode, I'm joined once again by mold investigator and building health expert Jason Earle, and we challenge some of the biggest assumptions surrounding mold illness.
Read MoreFor years we've talked about longevity as if the answer is hiding in the next supplement, biomarker, or miracle molecule. But what if we've been looking at aging through far too narrow a lens? Today's guest, Dr. Marios Kyriazis, has spent decades challenging that idea by exploring aging through medicine, complexity science, cybernetics, and even philosophy.
Read MoreToday, I’m joined by the insightful Dr. Scott Sherr, a pioneer in health optimization and mitochondrial medicine. In our conversation, Dr. Sherr introduces his groundbreaking concept—the "sympathetic spiral of doom"—and explains why so many high performers end up burned out, frustrated, and feeling like their nervous systems are working against them.
Read MoreToday, I’m joined by Nicole Bell, an accomplished engineer who made an unexpected leap from designing cutting-edge surgical robotics to becoming a powerful advocate for better diagnostics in tick-borne diseases. Nicole’s story is both deeply personal and urgent: after her husband was misdiagnosed with early-onset Alzheimer’s—only to later discover the true culprit was hidden tick-borne infections—she set out to uncover why our medical system misses these subtle yet devastating conditions.
Read MoreToday, I’m joined by Dr. Robin Rose, a double board-certified gastroenterologist and internal medicine physician who has become a true pioneer in the space of functional and precision medicine. Driven by a relentless curiosity that survived even the most rigid medical training, Dr. Rose shares how her quest to answer “why” led her beyond conventional medicine into root-cause healing, patient-centered care, and the world of gut health, biochemistry, and the microbiome.
Read MoreToday, I’m joined by the inspiring Dr. Anshul Gupta, a conventionally trained family physician who completely reimagined thyroid care after his own life and health hit a breaking point. Dr. Gupta shares how his battle with fatigue, weight gain, and relentless gut pain led him down a path beyond prescriptions, ultimately transforming his personal health and medical practice. Through functional medicine, he found a way out of his own struggle—and uncovered what so many thyroid patients are missing.
Read MoreToday, I'm joined by Dr. Taz Bhatia, a trailblazing integrative medicine physician, entrepreneur, and leading voice in women's health and longevity. In our conversation, Dr. Taz opens up about how her personal health challenges as a conventionally-trained MD led her to explore nutrition, Chinese medicine, and Ayurveda, inspiring her to reimagine what it means to truly care for the whole person.
Read MoreToday, I’m joined by the incredible Dr. Amie Hornaman, a leading thyroid expert and author of the brand new book, The Thyroid Fix. In our conversation, Dr. Hornaman opens up about her personal struggle with undiagnosed thyroid disease—a journey marked by frustrating medical gaslighting and the dismissive “you’re normal” diagnoses from doctor after doctor. She reveals how that experience led her to become a passionate advocate for women (and men) suffering from thyroid dysfunction and a pioneer in holistic, root-cause approaches to healing.
Read MoreToday, I’m thrilled to welcome Dr. Nasha Winters back to the show for part two of our powerful conversation. As a trailblazer in integrative oncology and a passionate advocate for the “metabolic terrain” approach to health, Dr. Winters brings both deep expertise and a truly holistic perspective to the complex world of cancer and longevity. In this episode, she doesn’t just share concepts—she takes us into the heart of what it means to test, assess, and address our own health in real life, especially when we’re facing major diagnoses and difficult decisions.
Read MoreToday, I’m joined by the legendary Dr. Jeffrey Bland, widely known as the “father of functional medicine” and a true pioneer in the science of longevity and immune resilience. In this conversation, Dr. Jeffrey Bland opens up about his decades-long journey questioning the conventional medicine model, the personal moments that shaped his mission, and how his passion for asking the right questions ultimately led him to reshape the future of healthcare.
Read MoreToday, I’m joined by Dr. Aimie Apigian, an innovative leader in the biology of trauma, whose work bridges the worlds of science, medicine, and lived experience. In our conversation, Dr. Apigian opens up about her journey from conventional medicine—where symptom management was the norm—to uncovering the physiological roots of trauma and the crucial role our nervous system plays in resilience and healing. She shares how her own health struggles, her work with adopted children, and a relentless curiosity led her to re-examine everything she thought she knew about stress, autoimmunity, and capacity.
Read MoreToday, I’m joined by the innovative Dr. Cynthia Keller, a pediatrician whose passion for integrative and functional medicine has reshaped how we understand post-COVID health challenges. Dr. Keller opens up about her journey from conventional medicine to designing unique solutions for children and families, revealing how her care, presence, and determination to “solve the unsolvable” led to breakthroughs in treating mood changes, weight gain, and energy loss after COVID.
Read MoreToday, I’m joined by Erin Ryan, my producer and long-time collaborator, for a special Q&A episode powered entirely by your questions. After our bioregulator deep dive with Dr. Bill Lawrence, the response was overwhelming—so many of you reached out with insightful queries about bioregulators, peptides, and the nuances between natural and synthetic options. Erin and I decided to tackle the most common themes, unpacking everything from organ versus system signaling to how bioregulators actually survive digestion.
Read MoreToday, I’m joined by the thoughtful Dr. Clement Lee, a naturopathic doctor blending ancient wisdom from Chinese medicine with cutting-edge regenerative therapies. In this episode, Dr. Lee gets real about why people can feel deeply unwell long before anything shows up on standard labs—and how subtle issues like limbic system stress, toxins, and chronic inflammation quietly undermine our vitality.
Read MoreToday, I’m joined by Dr. Stephen Hussey—a clinician, author of Understanding The Heart, and a powerful force in rethinking everything we thought we knew about heart disease. Dr. Hussey’s own journey began with type 1 diabetes as a child, and despite living a healthy, active lifestyle, he experienced a widowmaker heart attack at just 34 years old. In our conversation, he opens up about what it was like to face this crisis with “perfect” lab numbers, how it challenged his entire perspective, and ultimately led him to a radical new understanding of heart health and longevity.
Read MoreToday, I’m joined by the inspiring Dr. Jeffrey Gladden—a trailblazer in longevity medicine who once spent decades as an interventional cardiologist, only to challenge everything he knew after his own health hit a wall. Dr. Gladden opens up about the moment he refused to accept “normal for your age” as a diagnosis, launching himself into the world of functional and age-management medicine to reclaim his vitality and help others do the same.
Read MoreToday, I’m joined by Omid Moghadam, a serial inventor and biotech entrepreneur whose fascination with innovation has led him from the world of imaging and semiconductors to groundbreaking advancements in cancer screening. Omid shares how personal experiences—including his mother’s battle with cancer and his own early diagnosis—sparked his relentless drive to build better tools for early cancer detection.
Read MoreWe dive into societal pressures around food and alcohol, the impact of social media on mental health, and the need for nuance in health discussions. We also discuss the role of inflammation, neuroendocrine dysregulation, nutrient status, and neurotrophic factors in mental health disorders, while highlighting the need for objective lab testing to track physiological function and identify root causes.
Read MoreIn this episode, Andrew Wax and I discuss a model of healthcare that is designed to provide patients with a personalized healthcare plan and, even better, a personal healthcare team! Listen to case studies and learn why this model of care if more successful.
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