#420: Spermidine UNLOCKED: Reverse Aging, Boost Immunity & Thrive After 40 With Leslie Kenny
Today, I'm joined by the inspiring Leslie Kenny, Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable.
Together, we explore why biological age means more than the number on your birthday cake, the overlooked role of silent inflammation and immune resilience in aging, and why so many “healthy” habits can actually backfire for stressed or autoimmune-prone women. Leslie demystifies autophagy (your body’s cellular clean-up crew), breaks down the latest research behind spermidine, and shares how trauma, stress, and lifestyle all shape the way we age.
If you’re curious about the future of immune health, want actionable steps to rejuvenate your biology, or need hope that it’s never too late to thrive, this conversation is for you.
Leslie has a generous offer for you, when you visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout you’ll get 20% off.
Learn more from Leslie Kenny below:
Website: http://oxfordhealthspan.com/BIONAT20
Instagram: https://www.instagram.com/oxfordhealthspan/
What We Discuss:
Welcome, show intro, and overview ... 00:00:00
Leslie Kenny’s health journey and reversing disease ... 00:00:30
Biological vs. chronological age and the immune system ... 00:04:55
Impact of trauma and stress on aging ... 00:11:51
Overcoming prognosis: lifestyle and scientific interventions ... 00:18:02
Diet, tracking, and removing triggers ... 00:22:21
The overlooked importance of thyroid health ... 00:32:23
Dangers of overdoing fasting and hormesis ... 00:40:21
Autophagy basics and the cellular cleanup crew ... 00:44:06
Spermidine’s role, sourcing, and supplement quality ... 01:10:19
Optimizing longevity habits and daily routines ... 01:29:44
References
Mechanisms of spermidine-induced autophagy and geroprotection
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Higher spermidine intake is linked to lower mortality: a prospective population-based study
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Some episodes of the Longevity With Nathalie Niddam podcast are supported by partners whose products or services may be discussed during the show. The host may receive compensation or earn a minor commission if you purchase through affiliate links at no extra cost to you. All opinions shared are those of the host and guests, based on personal experience and research, and do not necessarily represent the views of any sponsor. Sponsorships do not imply medical endorsement or approval by any healthcare provider featured on this podcast.