#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum
Today, I’m joined by the insightful Courtney Van Bussum, a biomedical engineer and entrepreneur who has become a rising force in longevity science. Courtney shares how growing up in a family of healthcare innovators shaped her journey, and how she pivoted from startup life to tackling age-related challenges—especially when COVID brought her back to her roots and reignited her passion for cellular health.
We dive deep into the real science behind NAD+, uncovering why simply chasing higher levels can throw your cellular balance off, and why understanding the NAD ecosystem—from salvage pathways to methylation—is essential for healthy aging. Courtney gives practical advice on how to support your body’s natural resilience, reveals the dangers of over-supplementing, and introduces game-changing molecules like 1-MNA that few people know about.
If you’re curious about how to intelligently optimize your energy, immunity, and longevity—without falling for the hype—this episode is packed with actionable science, fresh perspectives, and plenty of clarity for your supplement strategy.
If you want to try Endotelio 1-MNA and save 10% click here and code NAT10 will be entered for you at checkout.
Learn more from Courtney Van Bussum below:
Website: https://ohphealth.com/products/endoteliol-1mna?sca_ref=9986562.lm23X9vLd2&sca_source=NatNiddam
Instagram: https://www.instagram.com/ohphealth/?hl=en
What We Discuss:
Welcome and introduction to Longevity Podcast ... 00:00:00
Challenging beliefs about aging and cellular health ... 00:12:00
Deep dive into NAD+ biochemistry and cellular function ... 00:13:08
NAD+/NADH balance: Why both matter ... 00:15:24
Why NAD+ declines: Not just aging, but increased degradation ...00:18:26
The role of CD38 and NMNT enzymes in NAD metabolism ... 00:20:14
Controversy and confusion: NAD+ precursors (NR, NMN) and IVs ... 00:22:28
Methylation’s hidden importance in NAD supplementation ... 00:30:55
Supplementing 1-MNA: Understanding dosages and applications ... 00:50:54
Assessing NAD+ status: Biomarkers and limitations of testing ... 00:53:01
Lifestyle ROI: Sleep, exercise, and circadian rhythm for NAD preservation ... 00:57:14
Ketones: Beyond performance, supporting cellular energy and longevity ... 01:06:03
Future of NAD science: Anticipating new insights and risks ... 01:11:45
Confidence and humility: Advice for navigating the longevity field ... 01:18:52
Our Amazing Sponsors:
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Gut Essentials Bundle by Just Thrive Health – This powerhouse duo pairs the only probiotic clinically proven to arrive 100% alive in your gut with science-backed Digestive Bitters to reduce bloat, curb cravings, and support better energy fast. Take the Just Thrive Feel Better Challenge and save 20% at justthrivehealth.com/NAT20 with code NAT20.
More from Nat:
For Transparency:
Some episodes of the Longevity With Nathalie Niddam podcast are supported by partners whose products or services may be discussed during the show. The host may receive compensation or earn a minor commission if you purchase through affiliate links at no extra cost to you. All opinions shared are those of the host and guests, based on personal experience and research, and do not necessarily represent the views of any sponsor. Sponsorships do not imply medical endorsement or approval by any healthcare provider featured on this podcast.