Today, I’m joined by the incredible Dr. Nora Abdul-Hussein, a physician-scientist, medical geneticist, and one of the leading voices in the field of genomic medicine. In this episode, Dr. Abdul-Hussein and I dig into a huge question—why do two people taking the exact same GLP-1 medication have such wildly different results, from weight loss to side effect profiles? She shares her unique path from internal medicine to cutting-edge population genomics, and how her work at 23andMe is beginning to answer some of medicine’s toughest puzzles.
Read MoreToday, I’m joined by Dan Pardi, a pioneering researcher who has dedicated years to understanding sleep, performance, and—the real focus of today’s conversation—the science of human energy. Dan unpacks how modern life is quietly draining our brain’s battery, and why brain energy, not just the march of time, could be the hidden driver of longevity.
Read MoreToday, I’m joined by Dr. Elisa Port, a trailblazing breast cancer surgeon and passionate advocate for women’s health. And the author of The Breast Advice In our conversation, Dr. Port traces her evolution from general surgery into breast surgery, sharing how the deeply collaborative decision-making with patients became her life’s calling. She gives an inside look at the optimism she found in this field—where advances in treatment have dramatically improved survival, offering hope and empowerment to countless women.
Read MoreToday, I’m joined by Dr. Jill Crista, a pioneering voice in environmental medicine and a relentless detective when it comes to chronic, mysterious illness. In our conversation, Dr. Crista reveals how she uncovered the hidden world of mold and mycotoxins—not just as respiratory irritants, but as stealthy drivers of fatigue, brain fog, hormone disruption, and accelerated aging. She shares her early experiences working with “non-responders” in Lyme disease, and how uncovering toxic mold exposures transformed her entire understanding of whole-body health.
Read MoreToday, I’m joined by Dr. Bill Lawrence, a leading researcher in longevity and pioneer in clinical studies on peptide bioregulators. Over the past eight years, Dr. Lawrence has dedicated himself to asking the big questions in longevity science: Do these interventions really work, and which strategies actually move the needle when it comes to living longer, healthier lives?
Read MoreToday, I’m mixing things up with a special episode that takes you on a tour through some of the most compelling moments from the past quarter. Rather than a typical interview or solo deep dive, I’ve curated standout clips from episodes that lit a fire under important longevity conversations and resonated deeply with both me and the team.
Read MoreFor years, we've been told to prioritize our muscles, our hormones, and our heart health—but what about our brains? Today's conversation explores why women are at a greater risk for Dementia and Alzheimer's, why brain changes begin decades before symptoms appear, and why so many warning signs are dismissed as "just stress" or "just menopause."
Read MoreMy guest today is James LaValle R.Ph., C.C.N. M.T. DHM, DHPh, one of the pioneers in functional and metabolic medicine, and we're unpacking the silent process he calls metaflammation—the chronic, low-grade inflammation that can quietly drive everything from fatigue and insulin resistance to hormone imbalances and accelerated aging.
Read MoreFollow my NEW Instagram @longevitywithnat
Most people think that if they can just find the right mold test, they'll finally have their answer. But what if that's exactly what's keeping them stuck? In this episode, I'm joined once again by mold investigator and building health expert Jason Earle, and we challenge some of the biggest assumptions surrounding mold illness.
Read MoreFor years we've talked about longevity as if the answer is hiding in the next supplement, biomarker, or miracle molecule. But what if we've been looking at aging through far too narrow a lens? Today's guest, Dr. Marios Kyriazis, has spent decades challenging that idea by exploring aging through medicine, complexity science, cybernetics, and even philosophy.
Read MoreIf you've been hearing everyone talk about exosomes but still aren't exactly sure what they are—or whether they're actually worth the hype—this episode is for you. Today I'm joined once again by Amitay Eshel and Anastasia Khodzhaeva from Young Goose to separate the science from the marketing and unpack what exosomes are really doing inside your skin.
Read MoreToday, I’m joined by the insightful Dr. Scott Sherr, a pioneer in health optimization and mitochondrial medicine. In our conversation, Dr. Sherr introduces his groundbreaking concept—the "sympathetic spiral of doom"—and explains why so many high performers end up burned out, frustrated, and feeling like their nervous systems are working against them.
Read MoreToday, I’m joined by Dr. Teo Soleymani, a renowned dermatological oncologist whose unique vantage point bridges the worlds of conventional medicine and longevity science. As someone who sees the real consequences of UV damage in his surgical practice while also advocating for a balanced, evidence-driven approach to sunlight and skin health, Dr. Teo Soleymani isn’t afraid to challenge the most entrenched ideas in modern skincare.
Read MoreToday, I’m joined by Alex Kikel—a name that’s become synonymous with pushing the frontiers of biology, performance, and healing. Alex is the kind of person who, when told “there’s nothing more we can do,” responds with, “but what if that’s not true?” In our conversation, he shares the pivotal moments that made him question everything about the standard approach to health, including his personal story of reversing serious conditions when traditional solutions failed.
Read MoreToday, I’m joined once again by the innovative Ian Mitchell, a name familiar to anyone passionate about radical longevity, biohacking, and pushing the boundaries of human performance. In this conversation, Ian pulls back the curtain on the science and surprising applications of C60—known as the “buckyball” molecule—and why it’s become such a powerful tool for both peak performance and healthy aging.
Read MoreToday, I’m joined by Nicole Bell, an accomplished engineer who made an unexpected leap from designing cutting-edge surgical robotics to becoming a powerful advocate for better diagnostics in tick-borne diseases. Nicole’s story is both deeply personal and urgent: after her husband was misdiagnosed with early-onset Alzheimer’s—only to later discover the true culprit was hidden tick-borne infections—she set out to uncover why our medical system misses these subtle yet devastating conditions.
Read MoreToday, I’m sitting down with the trailblazing Dr. Tyna Moore, a pioneer in reframing the conversation around GLP-1 medications. Instead of focusing solely on weight loss, Dr. Moore reveals how these powerful molecules can open a critical window to reset our health story—if we’re willing to harness that opportunity wisely.
Read MoreToday, I’m joined by Zach Abbott, a biotech innovator who took an unconventional path—from pharmaceutical science to the front lines of consumer health. Instead of following the well-worn route of drug development, Zach set his sights on bringing cutting-edge biotechnology directly to people, creating products designed not just for convenience, but for genuinely transforming our relationship with microbiology.
Read MoreToday, I’m joined by Dr. Robin Rose, a double board-certified gastroenterologist and internal medicine physician who has become a true pioneer in the space of functional and precision medicine. Driven by a relentless curiosity that survived even the most rigid medical training, Dr. Rose shares how her quest to answer “why” led her beyond conventional medicine into root-cause healing, patient-centered care, and the world of gut health, biochemistry, and the microbiome.
Read MoreToday, I’m joined by Dr. Andrew Salzman, a pioneer in NAD research whose work has spanned everything from pediatric sepsis to cutting-edge longevity science. Dr. Salzman dives deep into why NAD isn’t just another supplement buzzword, but a central molecule powering our energy, resilience, and even fertility.
Read More