#446: The NAD Code: Secrets to ENERGY, Aging, CD38, and Gut Health Breakthroughs With Dr. Andrew Salzman
Today, I’m joined by Dr. Andrew Salzman, a pioneer in NAD research whose work has spanned everything from pediatric sepsis to cutting-edge longevity science. Dr. Salzman dives deep into why NAD isn’t just another supplement buzzword, but a central molecule powering our energy, resilience, and even fertility.
In our conversation, we unpack the hidden role of inflammation—especially the enzyme CD38—in driving NAD depletion and cellular aging. Dr. Saltzman shares what most supplement companies get wrong, why rigor and humility are vital in longevity science, and how our gut health is intimately linked to the energy that fuels us at a cellular level.
Whether you’re just turning thirty or looking to optimize healthspan well into your eighties, this episode is packed with practical takeaways. Dr. Salzman breaks down the science of NAD and creatine, reveals surprising factors that drain your cellular batteries, and offers new insights on what it truly means to age well.
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Learn more from Dr. Andrew Salzman below:
Website: GetWonderFeel.com
What We Discuss:
Introduction ... 00:00:00
Scientific rigor in supplement development ... 00:06:49
Evolution of medicine and the role of populist health ... 00:09:37
Changing views on aging and longevity ... 00:14:13
NAD’s role in energy, repair, and aging ... 00:17:22
When NAD starts to decline and why it matters ... 00:21:06
Early signs of NAD deficiency ... 00:22:22
NAD’s connection to fertility and reproductive health ... 00:25:03
Gut health, inflammation, and NAD depletion ... 00:34:16
Lifestyle and diet drivers of NAD loss ... 00:39:35
How to assess NAD needs ... 00:42:11
Boosting NAD: supplement strategies and limits ... 00:44:09
NMN versus NR and dosing ... 00:46:05
Wonderfeel’s approach: address depletion and boost levels ... 00:51:53
Commonly reported results and user feedback ... 00:54:52
Creatine’s critical role in cellular energy and aging ... 00:57:55
Future directions: criticism, biomarkers, and personalization ... 01:10:10
Podcast wrap-up, offers, and disclaimer ... 01:15:09
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Some episodes of the Longevity With Nathalie Niddam podcast are supported by partners whose products or services may be discussed during the show. The host may receive compensation or earn a minor commission if you purchase through affiliate links at no extra cost to you. All opinions shared are those of the host and guests, based on personal experience and research, and do not necessarily represent the views of any sponsor. Sponsorships do not imply medical endorsement or approval by any healthcare provider featured on this podcast.