#381: Better Than Lasers: NAD+, Spermidine, and Methylene Blue for Youthful Skin | Amitay Eshel and Anastasia Khodzhaeva
Today, I’m joined by Amitay Eshel and Anastasia Khodzhaeva, the pioneering duo behind Young Goose and two of the earliest voices to bring longevity science into the world of skincare. Amitay comes from the red light therapy space, while Anastasia’s background is rooted in cancer research and regenerative medicine—together, their bold thesis is that youthful skin is not just about appearance, it’s an energy state.
We dive deep into why topical NAD is more effective for your face than IV or oral supplementation, how ingredients like spermidine and methylene blue drive cellular repair and help clear away those infamous “zombie cells,” and why choosing the right molecules matters far more than chasing quick fixes. Along the way, Amitay and Anastasia share stories of innovation, product development, and the research challenges that come with being first to market with longevity ingredients for skin.
If you’re curious about how cutting-edge science blends with beauty, and you want actionable tips to support vibrant, resilient skin for years to come, this episode is a treasure trove of expertise, new ideas, and inspiration.
Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you’re an existing customer.
Learn more from Amitay and Anastasia below:
Website: http://younggoose.com/
Instagram: https://www.instagram.com/young_goose_skincare/
YouTube: https://www.youtube.com/@AntiAgingSkinCareBiohacks2025
What We Discuss:
Skin longevity: appearance vs resilience vs long-term health ... 00:06:42
Why topical NAD matters for skin ... 00:14:07
Importance and decline of NAD as we age ... 00:18:26
Why spermidine was added to skincare ... 00:21:00
How spermidine drives autophagy and hydration ... 00:25:43
Spermidine’s impact on wrinkles and skin barrier ... 00:29:06
Longevity skincare vs traditional approaches ... 00:31:18
Methylene blue’s unique benefits and formulation ... 00:34:04
Methylene blue vs other antioxidants ... 00:36:16
Methylene blue’s role in recovery and protection ... 00:46:13
Platelet-derived, quantified exosomes explained ... 00:51:44
How to layer exosomes in your skincare ... 01:01:13
Biggest myths in skin longevity ... 01:02:41
Does topical NAD and spermidine really work? ... 01:08:28
Where to start with Young Goose products ... 01:19:33
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