#390: Muscle, Mitophagy, and Longevity: How Urolithin A Supports Healthy Aging and Athletic Performance With Brad Currier, PhD
Today, I’m joined by Dr. Brad Currier, Manager of Clinical Trials at Timeline Nutrition and an expert in the world of muscle and aging research. Brad is on the cutting edge of mitochondrial science, and in this episode, he helps us unravel the mysteries of why some 80-year-olds are still crushing it in the gym while others struggle to get up the stairs. We dive into his fascinating research on mitophagy—our bodies’ system for recycling dysfunctional mitochondria—and what it means for muscle health, strength, and vibrant aging.
We explore the powerful, but humble, molecule urolithin A—better known as Mitopure—which kickstarts cellular renewal and supports mitochondrial biogenesis. Brad breaks down how and why only a lucky few can produce enough urolithin A naturally, and what makes supplementation so important for the rest of us. Plus, we dig into real-world studies showing everything from boosted strength in sedentary adults to faster recovery for elite athletes, and the ripple effect this has on inflammation, immune health, and even skin and brain aging.
If you’ve ever wondered how to optimize your cellular health for longevity, or why mitochondria are at the heart of nearly every wellness conversation, this episode is packed with actionable science, fresh insights, and practical tips to help you get the most out of your body—at any age.
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Learn more from Brad Currier below:
Website: http://Timeline.com/nat20
What I Discuss:
Episode start … 00:00:00
What is Mitophagy? Why It Matters as We Age ... 00:04:53
Mitophagy in Athletes vs. General Population ... 00:07:15
Urolithin A and Why Most People Can’t Make It ... 00:12:12
What Mitopure Does: Mitophagy and Biogenesis ... 00:24:10
Key Study: Strength Gains in Middle-Aged Adults ... 00:26:43
Dose Guidance: 500mg vs. 1g ... 00:31:39
Anti-Inflammatory Effects and Immune Health ... 00:33:07
Benefits Beyond Muscle: Skin, Immunity, Brain ... 00:35:01
Weightlifter Study: Performance in Trained Athletes ... 00:40:34
Mitopure for Recovery and User Experiences ... 00:46:41
How to Use Mitopure: Timing, Dosage, Consistency ... 00:52:54
Protein, Creatine, and Mitopure: The Basics Stack ... 00:53:41
Recovery, Cycling, and How Soon Benefits Appear ... 00:58:44
Debunking Myths: Pomegranate, Antioxidant, Athletes Only ... 01:10:26
Mitopure vs. Generic Urolithin A: Safety Concerns ... 01:13:39
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