#477: Stimulate Don't Suppress: How Natural GLP-1 Hormones Beat Synthetic for Sustainable Fat Loss | Clinical Results With Sarah Kennedy
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Today, I’m joined by Sarah Kennedy of CaloCurb, a remarkable veterinarian-turned-nutrition expert who brings decades of hands-on research and real-world insight to the weight loss conversation. Sarah shares her unique journey from studying animal nutrition—where performance and health are paramount—to spearheading groundbreaking human clinical trials in appetite regulation, hunger hormones, and innovative, natural GLP-1 strategies.
Together, we dig into what most diets and mainstream advice get wrong about willpower and weight regulation, how your primitive brain and modern food environment are at odds, and the latest science behind “food noise,” cravings, and the gut-brain axis. Sarah pulls back the curtain on a landmark 24-week trial achieving significant weight loss while preserving lean muscle, why body composition matters so much more than the scale, and how natural approaches can reboot your appetite and energy—without the side effects or loss of pleasure that often come with pharmaceutical options.
If you want a deeper understanding of how to truly work with your biology for sustainable fat loss, the surprising role of bitter compounds, and practical ways to support healthy longevity, this episode is filled with both cutting-edge wisdom a
Learn more about Calocurb at https://www.calocurb.com/?sca_ref=12093749.1gzbGYmTyb and use code NAT for 10% off.
What We Discuss:
Welcome and gratitude for listeners ... 00:00:00
Calocurb and GLP-1 context ... 00:02:07
Bitter taste receptors and appetite suppression ... 00:17:13
Discovery of hops as key bitter extract ... 00:20:13
Human trials: hormone changes and calorie reduction ... 00:21:00
Comparison to pharmaceutical GLP-1s ... 00:21:44
Appetite studies: women vs. men ... 00:25:15
Recent clinical trial: fat loss, muscle preservation ... 00:28:37
Mechanisms: natural vs. synthetic hormone activation ... 00:31:38
Lasting effects after stopping Calocurb ... 00:34:16
Practical use cases: intermittent fasting, holidays, maintenance ... 00:36:33
Comparison: behavioral effects and food noise ... 00:37:03
Side effects: GI motility, constipation, and laxative effect ... 00:45:03
Calocurb vs. other "GLP-1" supplements ... 00:51:53
Blood sugar effects and limitations ... 00:55:51
Managing late eating and habit change ... 00:59:10
Safety considerations (GI conditions, pregnancy) ... 01:03:23
Older adults, menopause, and ongoing research ... 01:04:50
PYY, muscle satellite cells, and aging ... 01:07:36
Why it's hard to "just use food" for appetite control ... 01:08:41
Coming off pharmaceuticals: rebooting gut-brain axis ... 01:10:25
Open research questions and clinical focus ... 01:12:30
Natural vs. synthetic: critical difference explained ... 01:14:26
Sarah Kennedy's personal experience with food and Calocurb ... 01:16:16
Quickfire round: what’s overhyped, underrated, needs more data ... 01:17:53
Final takeaway: primitive brain, not willpower ... 01:19:09
Where to learn more and closing remarks ... 01:19:44
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Some episodes of the Longevity With Nathalie Niddam podcast are supported by partners whose products or services may be discussed during the show. The host may receive compensation or earn a minor commission if you purchase through affiliate links at no extra cost to you. All opinions shared are those of the host and guests, based on personal experience and research, and do not necessarily represent the views of any sponsor. Sponsorships do not imply medical endorsement or approval by any healthcare provider featured on this podcast.