#373 NEW Longevity Breakthroughs & The Science of Stress | Kiran Krishnan on Bioactive HERBS and the Myth of Cheap Supplements
Today, I’m joined by Kiran Krishnan, a celebrated scientist best known as the innovative mind behind spore-based probiotics and someone who’s made waves in both the practitioner and consumer health spaces. In this conversation, Kiran shares what inspired his leap from the world of microbiome science into the realm of ancestral and Ayurvedic medicine—specifically, his groundbreaking work with novel bioactives derived from the Ashwagandha root.
Together, we unpack how the latest advancements in analytical chemistry have allowed Kiran and his team at Regenerive to unlock previously untapped compounds in Ashwagandha, leading to remarkably profound results for longevity. He breaks down the science behind these discoveries, what sets their extract—LongeFera—apart from typical adaptogen supplements, and the compelling clinical research showing improvements in genetic expression, telomere length, strength, stress, and overall markers of healthy aging.
If you’re fascinated by the intersection of tradition and cutting-edge science, and you want to know how targeted plant compounds can supercharge your healthspan, this episode is packed with fresh insights and actionable takeaways.
To find out more, visit regenerive.co and use code NAT25 for 25% off.
Learn more from Kiran Krishnan below:
Website: regenerive.co
Instagram: @kiranbiome
What We Discuss:
Kiran Krishnan’s background and Regenerive overview ... 00:00:30
The promise and problems of herbal/Ayurvedic medicine ... 00:05:31
Ashwagandha: extraction, quality, and toxicity issues ... 00:11:02
Discovery of new Ashwagandha bioactives (ASHx4) ... 00:21:27
Preclinical and human clinical results (longevity, sirtuins, telomeres) ... 00:23:09
Physical and metabolic benefits in aging adults ... 00:48:33
Safety and dosing of Longfara supplement ... 00:57:38
Biohacks and healthy aging habits from Kiran ... 01:04:49
How to get Regenerive and wrap-up ... 01:07:32
Our Amazing Sponsors:
Tro Zzz by Troscriptions - This isn’t just melatonin—it’s a powerhouse! Oblipair gives you honokiol and agarin to enhance GABA binding, while adenosine and cordycepin boost sleep drive and deep sleep. CBD, CBN, and 5‑HTP round it out. Head to troscriptions.com, use NAT10, and get 10% off your first order.
NAD+ By Qualia - A groundbreaking formula that can increase NAD+ levels by up to 67%, using three of the most powerful precursors known to science: niacin, niacinamide, and NIAGEN. Go to qualialife.com/NATHALIE and use promo code NATHALIE to get 15% off—and try it risk-free with their 100-day money-back guarantee.
Manukora honey - From remote forests in New Zealand, where bees collect nectar from the native Manuka tea tree. That nectar is naturally rich in antibacterial compounds like MGO, plus antioxidants and prebiotics that support immunity and gut health. Visit manukora.com/NAT to save up to 31% plus $25 worth of free gifts with the Starter Kit - you’ll get an MGO 850+ Manuka Honey jar, 5 travel sticks, a wooden spoon, and a guidebook.
More from Nat: