#337 Solo: This Tiny Molecule Can Tackle Inflammation & Immune Health - Diving into KPV with Nathalie Niddam
In this special solo episode, it’s just me, Nathalie Niddam—nutritionist, human potential and epigenetic coach—returning to my roots and diving deep into the world of peptides. Today, I’m shining a spotlight on KPV, a fascinating and often overlooked peptide with powerful anti-inflammatory, antimicrobial, and healing properties.
Whether you’re brand new to peptides or have been exploring them for a while, I’ll break down exactly what peptides are, how they work, and why KPV could become a key part of your health optimization toolkit. We’ll cover everything from its impact on gut health and skin repair to immune system balance and even neuroprotection. I’ll also share tips on sourcing these peptides, the importance of tracking your protocols, and introduce you to the Peptide Pro App: (Visitwww.peptidepro.app to download the app and use code NATHALIE50 to receive 50% off for the first month.) —a fantastic new tool that makes peptide experimentation safer and more organized. If you’re curious about staying on the cutting edge of health and longevity, you won’t want to miss this episode!
What Nat Discusses
What are peptides? Clearing up misconceptions ... 00:01:00
KPV explained: structure and origins ... 00:03:00
How KPV works (anti-inflammatory mechanisms) ... 00:05:00
Comparison to Melanotan and tanning ... 00:08:00
KPV benefits: gut, antimicrobial, healing, immune modulation ... 00:09:00
KPV for gut and skin health ... 00:14:00
Neuroprotection and research potential ... 00:18:00
Administration methods: oral, topical, injectable ... 00:19:00
Safety profile and side effects ... 00:22:00
Tracking protocols and the Peptide Pro app ... 00:24:00
Recap and concluding remarks ... 00:30:00
Episode Resources:
Mechanism of Action & PepT1 Transport
PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation
[PMCID: PMC2431115]Demonstrates that KPV’s anti-inflammatory effect in intestinal epithelial and immune cells is mediated by the PepT1 transporter, not by melanocortin receptors. Shows KPV’s efficacy in mouse models of colitis and its inhibition of NF-κB and MAPK pathways, leading to reduced cytokine production.
Targeted Delivery and Efficacy in Colitis
Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid Functionalized Nanoparticles for Colitis Therapy
[PMCID: PMC5498804]Describes the use of hyaluronic acid nanoparticles to deliver KPV directly to inflamed colonic tissue, accelerating mucosal healing and alleviating inflammation in ulcerative colitis models. Confirms biocompatibility and lack of toxicity in intestinal cells.
Mechanistic Insights and Broader Anti-inflammatory Effects
Mechanism of KPV Action and a Role for MC3R Agonists
[PMCID: PMC3403564]Explores the molecular mechanisms of KPV, including its interaction with intracellular targets after PepT1-mediated transport and its independence from melanocortin receptor signaling.
Summary of Research and Clinical Potential
Exploring KPV Peptide and Inflammation
[CorePeptides.com, December 2024]Summarizes preclinical and early clinical research on KPV’s anti-inflammatory, mucosal healing, and wound healing properties. Reviews studies on KPV’s effect in animal models and its independence from MC1R signaling.
Clinical Applications, Administration, and Dosage
KPV: The Microscopic Miracle Peptide for Inflammation, Skin Health, and Gut Repair
[RWA Center, April 2025]Discusses routes of administration (oral, topical, injectable, nasal), typical dosages, and clinical evidence for KPV’s use in gut and skin health. Highlights its favorable safety profile and minimal side effects compared to conventional anti-inflammatories.
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